Neuron loss in schizophrenia and depression could be prevented, study suggests

Gamma-aminobutyric acid (GABA) deficits have been implicated in schizophrenia and depression. In schizophrenia, deficits have been particularly well-described for a subtype of GABA neuron, the parvalbumin fast-spiking interneurons. The activity of these neurons is critical for proper cognitive and emotional functioning. It now appears that parvalbumin neurons are particularly vulnerable to oxidative stress, a factor that may emerge commonly in development, particularly in the context of psychiatric disorders like schizophrenia or bipolar disorder, where compromised mitochondrial function plays a role.

URL: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/depression/~3/oMJKnYsO9z8/130313095533.htm